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X-rays For Early Alzheimer's Detection

Researchers at the U.S. Department of Energy’s Laboratory have demonstrated a new, highly detailed x-ray imaging technique that could be developed into a method for early diagnosis of Alzheimer’s disease.

The technique has previously been used to look at tumors in breast tissue and cartilage in human knee and ankle joints, but this study is the first to test its ability to visualize a class of miniscule plaques that are a hallmark feature of Alzheimer’s disease. Their results will appear in a July 2009 edition of the journal NeuroImage.

Scientists have long known that Alzheimer’s disease is associated with plaques, areas of dense built-up proteins, in the affected brain. Many also believe that these plaques, called amyloid beta (Aß) plaques after the protein they contain, actually cause the disease. A major goal is to develop a drug that removes the plaques from the brain. However, before drug therapies can be tested, researchers need a non-invasive, safe, and cost-effective way to track the plaques’ number and size.

The technique developed is called diffraction-enhanced imaging (DEI), might provide the extra imaging power researchers crave. DEI, which makes use of extremely bright beams of x-rays available at synchrotron sources such as Brookhaven’s National Synchrotron Light Source, is used to visualize not only bone, but also soft tissue in a way that is not possible using standard x-rays. In contrast to conventional sources, synchrotron x-ray beams are thousands of times more intense and extremely concentrated into a narrow beam. The result is typically a lower x-ray dose with a higher image quality.

In this study, researchers from Brookhaven and Stony Brook University used DEI in a high-resolution mode called micro-computed tomography to visualize individual plaques in a mouse-brain model of Alzheimer’s disease. The results not only revealed detailed images of the plaques, but also proved that DEI can be used on whole brains to visualize a wide range of anatomical structures without the use of a contrast agent.

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